If you would like your order to be shipped by a specific courier, please inform us when you place the order. The costs of low dose and high dose of Andexxa are approximately $29,040 and $58,080, respectively. European Commission Grants Conditional Marketing Authorization for Portola Pharmaceuticals’ Ondexxya™ (coagulation factor Xa (recombinant), inactivated-zhzo), the First and Only Antidote for the Reversal of Factor Xa Inhibitors The shipping fee might also include the cost of special packaging, such as coolboxes, cool packs and data loggers, as well as transport insurance to guarantee that you receive your medicine in good order. We do not have any partnership with distributors, agents or any other entities. Thromboembolism is obstruction in vessels due to formation of blood clots. The European Medicines Agency (EMA), Europe, on April 26, 2019. Create an account with us to view and manage your quotes, import documents, prescriptions and more. The shipping cost depends on the medicine and the destination country. Andexanet alfa, sold under the trade name Andexxa among others, is an antidote for the medications rivaroxaban and apixaban, when reversal of anticoagulation is needed due to uncontrolled bleeding. Important: When there is a range of pricing, consumers should normally expect to pay the lower price. I want the guide for importing medicine into... By clicking "Download guide", you agree to receive emails from TheSocialMedwork (including the TheSocialMedwork newsletter and announcements). Acquisition cost: 100 mg vial: $2750 (To be phased out per US FDA) 200 mg vial: $5500. When paying by credit card, you can pay online once you have received your order confirmation. Based on the average mean dose in a retrospective study of 4-Factor PCC in FXa inhibitor-related bleeding, it could cost around $4973 per treatment [40]. To date we have successfully delivered packages to over 75 countries around the world. Check if we have sent medicines to yours. 8 mg/min for up to 120 minutes (960 mg) 9 (4 vials bolus + 5 vials infusion) *The safety and effectiveness of more than one dose have not been evaluated. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Within 2 minutes following the IV bolus, administer the continuous IV infusion for up to 120 minutes. At an estimated price of $28,000 per dose this would represent shipments that could treat about 275 patients ($7.7 million divided by the $28,000 estimated price per patient). Patient assistance programs (PAPs) are usually sponsored by pharmaceutical companies and provide free or We have delivered medicines to more than 88 countries. You'll find more details highlighted below. Please note: This is a drug discount program, not an insurance plan. Our Patient Support team will guide you throughout the process. Reduced by 94% in the group that received an andexanet bolus, as compared to the 21% reduction that was seen in the placebo group, in participants receiving Apixaban. 5 g kit: ~ $3500 to 4200a a May vary by vendor. Valid at all major chains including Walgreens, CVS Pharmacy, Target, WalMart Pharmacy, It has not been found to be useful for other factor Xa inhibitors. For any questions, make an enquiry and we'll be happy to help. In some limited circumstances, we do accept insurance. Eligibility requirements vary for each program. Please be aware that due to the COVID-19 situation worldwide and the country lockdowns, we will sometimes experience delays in shipping and shortages in availability. In most cases we will respond to you via email, however for more complex situations, a call ensures we can process your request faster. They are reliable, honest, punctual and do everything to meet your needs…”, “Dr. It is available to order as well. J9177 Injection, enfortumab vedotin-ejfv, 0.25 mg If you don't already have a prescription for this medicine, download our “Easy Prescription Guideline”. The base cost of each medicine is set by the manufacturer. • Cost - ~$27,500 to $50,000 per dose ANDEXXA® (coagulation factor Xa (recombinant), inacti vated-zhzo) package insert. 80% or more off the cost of prescription medicines, over-the-counter drugs and pet prescriptions. At the time of writing, andexanet is $22,000 per package of four 200mg vials. There are currently no Patient Assistance Programs that we know about for this drug. WALMART PHARMACY. Download Dosing Guide. By Marina Haque, Michael Gratson & 2 more. (4 vials bolus + 5 vials infusion) The recommended dosing of Andexxa is based on the specific FXa inhibitor, dose of FXa inhibitor, and time since the patient's last dose of FXa inhibitor (see Table 2 ). When you buy Ondexxya (andexanet alfa), you can make the payment by bank transfer or by credit card. Disclaimer: The price indicated in USD ($) is an estimated price for your reference. Duane Reade and 65,000 pharmacies nationwide. It works by binding and sequestering FXa inhibitors, making them unable to promote anticoagulation. June 18, 2018 (Issue: 1549) Coagulation factor Xa (recombinant), inactivated-zhzo (andexanet alfa; Andexxa – Portola) has received accelerated approval from the FDA for urgent reversal of the anticoagulant effect of the direct factor Xa inhibitors apixaban (Eliquis) and rivaroxaban (Xarelto). It is given by injection into a vein.. Common side effects include pneumonia and urinary tract infections. Here are some crowdfunding platforms where you can seek support: GoFundMe, GiveForward, FundRazr and Watsi. Effective for the Fiscal Year 2019 starting October 1, 2018, the maximum NTAP for a case involving the use of Andexxa is $14,062.50, or 50 percent of the wholesale acquisition cost … Treating patients with a reversal agent such as Ondexxya increases their thrombotic risk. JavaScript seems to be disabled in your browser. The shipping prices are dependent on the type of shipping necessary for the particular medicine (regular or cold chain) and upon the destination country. Andexxa Prices. 3040 College Park Dr. 3040 College Park Dr. A Study in Older Subjects to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Apixaban Fill out this form to enquire about Ondexxya (andexanet alfa). Andexxa offers may be in the form of a printable coupon, rebate, savings card, trial offer, or free samples. European Commission Grants Conditional Marketing Authorization for Portola Pharmaceuticals’ Ondexxya™ (andexanet alfa), the First and Only Antidote for the Reversal of Factor Xa Inhibitors A Study in Older Subject to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Rivaroxaban Low-dose regimen: initially 400mg (target rate: 30mg/min) as IV bolus, followed by 4mg/min IV infusion for up to 120mins. Low titers of anti-ANDEXXA antibodies were observed in 26/145 healthy subjects (17%); 6% (9/145) were first observed at Day 30 with 20 subjects (14%) still having titers at the last time point (Days 44 to 48). Collected information will not be shared with any third party and complies with our stated Privacy Policy. ~ $1.60 to 2.77 per unit: $1.64/unita a May vary by vendor. From your side, we’ll simply need a prescription from your treating doctor. Select your preferred country and input your email to receive a step by step guide on how we can help you legally and safely import a medicine that is not approved in your country. 8 mg/min for up to 120 minutes (960 mg) 9. The best thing would be to check with your country's own health ministry. therapeutically effective.8 Conversely, 1 dose of Andexxa will typically cost between $24,750 and $49,500 alone; it does not need to be administered alongside PCC or aPCC. Clinical trial ANNEXXA-A (NCT02207725), last updated on Oct 1, 2018, 4. We are committed to the Ethical Principles of the World Medical Association. Select one or more newsletters to continue. Table 1: ANDEXXA Dosing Regimens . Note: Please consult with your treating doctor for personalised dosing. The price of the medicines you see on sale is the cost set by the manufacturer. The cost for Andexxa intravenous powder for injection (recombinant, inactivated 200 mg) is around $22,978 for a supply of 4 powder for injection, depending on the pharmacy you visit. For instructions on reconstitution of the medicinal product before administration, see section 6.6. DA: 23 PA: 51 MOZ Rank: 46. TheSocialMedwork provides access to Ondexxya (andexanet alfa) on the Named Patient import basis, which means that we work on behalf of the patient in cooperation with their treating doctor. Portola Pharmaceuticals press release, Apr 26, 2019, 2. In randomized clinical trials, factor Xa inhibitors have been shown to be safe and effective for the treatment and prevention of venous thromboembolism and for stroke prevention in patients with atrial fibrillation.1-4 However, factor Xa inhibitors have been associated with major and even fatal bleeding events.1-4 Such episodes of acute major bleeding may be difficult to treat because there is no reversal agent. There are currently no Manufacturer Promotions that we know about for this drug. Three to four hours after last dosage, participants received either Ondexxya or placebo as a bolus or as a bolus plus a 2-hour infusion.2,3, The main efficacy outcome was the mean percent change in anti–FXa activity, which is a measure of FXa inhibition by the anticoagulant.2,3, Ondexxya rapidly reversed the anticoagulant activity of apixaban and rivaroxaban in healthy participants within minutes after administration and for the duration of infusion.4, Treatment with Ondexxya showed no evidence of clinical toxic effects.4, Please refer to the summary of product characteristics below and in the resource section for comprehensive information about the safety and effectiveness of Ondexxya (andexanet alfa) for the approved indication.5, 1. The wholesale acquisition cost of the standard dose regimen is $24,750, and the high-dose regimen is $49,500. 6,9 While data suggest that Andexxa may be highly Some offers may be printed right from a website, others require registration, completing a questionnaire, Some countries have a government fund providing financial assistance for citizens to access lifesaving medical treatment abroad. How and where to buy Ondexxya: You can order Ondexxya from TheSocialMedwork if the drug has not been approved or is not available in your country. Make an enquiry for more information. J7333 Hyaluronan or derivative, visco-3, for intra-articular injection, per dose. Andexanet Alfa (Andexxa) Formulary Review nih.gov Submit a request for a specific medicine, or a general request, and your Patient Support Manager will contact you within 24 hours. Arterial and venous thromboembolic events, Ischemic events, including myocardial infarction and ischemic stroke. The price, packaging size and strength may vary due to product availability. Low Dose 400 mg at a target rate For the best experience on our site, be sure to turn on Javascript in your browser. It might be possible for you to claim the cost of Ondexxya (andexanet alfa) via your country's healthcare system. J7169 Injection, coagulation factor xa (recombinant), inactivated-zhzo (andexxa), 10 mg. J7204 Injection, factor viii, antihemophilic factor (recombinant), (esperoct), glycopegylated-exei, per iu. You can read a detailed overview of prices and costs here. Make an enquiry below to learn more. Generally, our Named Patient support fee, shipping costs and any local tax (if applicable) are not included in the product price that is displayed on our website unless stated otherwise. We support you to access approved medicine that is not approved or available in your country of residence. We will never share your number with 3rd parties. The studies involved a total of 148 healthy volunteers that were treated with apaxiban or rivaroxaban.2,3, Participants were given 5 mg of apixaban two times per day, or 20 mg of rivaroxaban once daily. Administer the IV bolus dose at approximately 30 mg/min. The cost of Kcentra® is $1.27 per unit; a single dose of Kcentra® for an 80 kg patient costs … This necessitates a bolus and an infusion. These effects were still seen when Andexxa was given as a bolus plus an infusion. Payments are fully encrypted and secure. Kcentra® is dosed according to Factor IX potency and is individualized based on the patient’s baseline International Normalized Ratio (INR) and body weight. Since we help patients access medicines not available in their home country, our first step is to check that the medicine you need is not currently available in your home country. Get Coupon. In addition, shipping costs and a Named Patient support fee will apply. Your order will be shipped to you by our partner couriers, such as DHL, UPS and specialised cold chain couriers. I was in a very difficult situation with a tight schedule, and their amazing team members…”. Scroll below to download the import guide for your country. Expand to see all locations within your area. The cost for a monthly or yearly treatment of Ondexxya (andexanet alfa) depends on your prescription requirements which includes the dosage in mg and medicine type ( 4 single-use vials). 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